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However, heterogeneous results have been observed by way of T cell infiltration, suggesting a special potential benefit after ICI therapies. It has been proposed that neoAg-specific T cells play a outstanding function in ICI efficacy, since TMB correlates with the response rate to those therapies . Analyses of expression of mutated sequences revealed that about 65% of mutations have been located at expressed genes. A high variability concerning expression of mutated genes with potential neoAg-coding capacity has been reported in TNBC, starting from 35-50% in some instances , to greater than 80% in others . The sample size and the filtering criteria used to outline expression within the completely different research may account for these discrepancies, in addition to for the differences with our results.

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BA, DR, MR, DL, LS, EV, PT, IT, CS and AI performed the in silico, in vitro and in vivo research. BA, SH-S, JL and PS analyzed knowledge and wrote the manuscript. All authors reviewed and permitted the manuscript.

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